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Exenatide fue el primer agonista del receptor de GLP-1 que se aprobó para el tratamiento de la diabetes tipo 2 en 2005. Su nombre comercial era Byetta y se inyectaba 2 veces al día. En 2010 llegó liraglutide. Inicialmente se comercializó con el nombre de Victoza y estaba indicado para el tratamiento de la diabetes tipo 2. En 2015 se aprobó su uso para el tratamiento de la obesidad bajo el nombre comercial de Saxenda. Supuso un avance frente a exenatide ya que la inyección se administraba una vez
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