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Video: Somatic to iPS Cell Reprogramming
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著作权归作者所有。商业转载请联系作者获得授权，非商业转载请注明出处。 人类的生物学身体的所有“设定”都不能支持“解除自然寿命限制”的低级永生，距离无法死亡（既没有寿命限制也无法被杀死）太过遥远。 不过，这情况似乎能被技术改变。 2023 年 1 月 12 日，David Sinclair 等在 Cell 期刊发表了题为 Loss of epigenetic information as a cause of mammalian aging 的论文：历时 13 年的研究证明，表观遗传变化是导致哺乳动物衰老的主要原因，恢复表观基因组的完整性可以逆转衰老的诸多表现。 2023 年 7 月 12 日，David Sinclair 等发表了化学重编程逆转细胞衰老的论文[1]。不过，David Sinclair 在 NMN 等物质上的不当炒作让他的名誉受损，他的很多话并不可信。 不止是题目谈到的牙齿，人体所有的器官都在随着时间走向衰亡。一般人类细胞在细胞培养环境下分裂的次数有限（成纤维细胞为 52 到 56 次），这受表观遗传变化（主要是 DNA 甲基化、组蛋白乙酰化的模式改变）、端粒长度、端粒酶
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