In silico antibody accessibility analysis indicates that ectodomain epitopes are transiently exposed, while MPER epitopes are virtually always occluded in the pre-fusion trimer.

Conformational change of a biomolecule—a change in its structure—is the ultimate basis for signaling in biology. A convenient and direct way of detecting structural changes in protein targets, and one ...

Recently, the research team of Prof. WANG Qian from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) and Prof. BAI Fang from ShanghaiTech University ...

In a recent Current Research in Structural Biology study, researchers demonstrate that the energy landscape of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits significant ...

The way proteins move is often what gives them biological activity: they can open, close, twist, and rearrange themselves in ways that allow them to bind to other molecules or perform complex ...