Expression of the Notch ligand JAG1 and Notch pathway activation promote poor prognosis, basal-like breast cancer. We have recently shown that the pseudokinase Tribbles homolog 3 (TRB3) regulates JAG1 ...

The effect of TRB3 on Akt/PKB was to inhibit its phosphorylation at threonine (Thr) 308 and serine (Ser) 473, thereby reducing its kinase activity — there was no change in the protein levels of ...

Three pseudo kinases of the Tribbles family have been recently recognized, which include TRB1, TRB2 and TRB3. Recent research has found that the expression of hepatic TRB3 increased in a rat model of ...

U.S. researchers have identified a protein that could serve as a new target for drugs designed to treat type II diabetes. The protein, known as TRB3, is actually a homolog of a protein found in the ...

Type 2 diabetes is characterized by insulin resistance—defined as a failure of insulin to promote glucose uptake in muscle and to suppress glucose production in liver. The serine-threonine kinase Akt ...

Non-alcoholic fatty liver disease has increased in recent years, and is one of the major causes for cryptogenic cirrhosis. Tribble 3 is a mammalian homolog of drosophila tribbles and is also a ...