After three years of study, the researchers found that alpha-synuclein, a protein closely linked to Parkinson’s disease, ...

Alpha synuclein is a key drug target in Parkinson's Disease with the ability to aggregate into oligomers and fibrils. Research into α-synuclein has rapidly progressed in recent years with a lot of the ...

Two proteins found on the surface of motor neurons in the brain may be essential in the progression of Parkinson's disease, according to new Yale School of Medicine (YSM) research.

Much of the research into α-synuclein, the major component of Lewy bodies in Parkinson’s and other neurodegenerative diseases, focuses on its role in synaptic vesicles and membranes. But could other ...

More than a decade has passed since researchers led by Dennis Selkoe of Brigham and Women’s Hospital in Boston first reported that when α-synuclein has its druthers, it prefers the company of three ...

Studies have uncovered that abnormalities in the alpha-synuclein protein are likely a causal factor for numerous diseases, including Parkinson’s disease, multiple system atrophy (MSA), dementia with ...

Proteins form the building blocks of life, but when they form unusual clumps inside the brain, they raise an alarm that something isn't right.

In Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, accumulation of aggregates of abnormally phosphorylated α-synuclein is observed, and these diseases are collectively ...

Amsterdam, NL, November 13, 2019 - Aggregates of the protein alpha-synuclein arising in the gut may play a key role in the development of Parkinson's disease (PD). Investigators are testing the ...

Multiple system atrophy (MSA) is a neurodegenerative disorder characterized by the aggregation of alpha-synuclein in the brain. Now, scientists have developed a radioligand that facilitates the ...