In drug discovery, various methods of lead generation exist that give researchers a starting point to develop drugs further and make them as efficacious as possible. High-throughput screening is a ...

The chemical scaffolds from which screening libraries are built have strong influence on the libraries' utility for screening campaigns. Here we present analysis of the scaffold composition of several ...

The screening of large compound libraries to identify hit compounds involves a number of laborious liquid-handling stages. Plate preparation for compound screening and bioassays involves sample ...

In lead discovery, libraries of 10 6 molecules are screened for biological activity. Given the over 10 60 drug-like molecules thought possible, such screens might never succeed. The fact that they do, ...

The identification of compounds that could be promising candidates for drug development has become easier following research by the Walter and Eliza Hall Institute's medicinal chemistry group. Dr ...

Proteins with desirable properties are often identified by screening libraries of related gene sequences. Successful applications include antibody engineering, vaccine development, and biocatalyst ...

Generation of fragment screening libraries could enhance the analysis and application of natural products for medicinal chemistry and drug discovery, according to researchers. In a new article, ...

Synthego, the genome engineering company, today announced it received the Technology Award at the European Laboratory Research & Innovation Group’s (ELRIG) CRISPR in Drug Discovery 2020 meeting in ...