Covariate-adaptive randomization represents an advanced methodology in the design of clinical trials, ensuring a balanced distribution of prognostic factors among treatment groups. This approach ...

The coronavirus disease 2019 (Covid-19) pandemic has highlighted the crucial role of randomized trials in guiding clinical practice and the need for designs that provide rapid evaluation of multiple ...

Multiple randomized clinical trials and electronic health record studies now show that metformin, a widely used and well-established medication, significantly reduces the risk of developing long COVID ...

An expert from the FDA explained the benefits and limitations of these two clinical trial formats and how the cancer field can learn from both. The use of single-arm trials, in which all patients ...

Randomization Techniques (60 minutes): In this workshop, the rationale behind randomized experiments will be explained. Descriptions of commonly utilized randomization algorithms will be presented, ...

Infection and increased systemic inflammation cause organ dysfunction and death in patients with decompensated cirrhosis. Preclinical studies provide support for an antiinflammatory role of albumin, ...

We are witnessing an increasing demand for rapid, rigorous, and generalizable evidence to inform health care systems’ learning and address inefficiencies in the current clinical trials landscape.