Adaptor protein (AP) complexes play central roles in intracellular vesicular trafficking by coupling cargo selection to ...

Misfolded proteins can appear as small aggregates, soluble monomers, or large insoluble inclusion bodies. While the fundamental biophysical mechanisms that cause cytotoxicity are not fully understood, ...

The way proteins move is often what gives them biological activity: they can open, close, twist, and rearrange themselves in ways that allow them to bind to other molecules or perform complex ...

By extending a naturally rigid bacterial protein by 50% while preserving geometry and stability, the study introduces protein ...

The strategies biopharmaceutical manufacturers currently use to limit protein misfolding are complex, time-consuming, and generate low yields with only limited scalability. Covalent organic frameworks ...

While protein design is experiencing a period of rapid development and advancement, there’s one particularly challenging class of proteins that’s giving researchers a hard time: enzymes. Now ...

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert ...