Researchers created long noncoding RNA targeting inflammatory pathways. The approach reduced cytokine production in human cell cultures and mouse models, demonstrating a novel strategy for RNA-based ...

The authors conclude that mRNA vaccines “induce a gene-altering [mode of action], reprogramming host expression programs” that go far beyond inflammatory responses to Spike protein. Effects include ...

Biology textbooks explain that cells follow a universal rule when processing gene transcripts to make proteins. Non-coding ...

When a gene produces too much protein, it can have devastating consequences on brain development and function. Patients with an overproduction of protein from the chromodomain helicase DNA binding ...

When AlphaFold solved the protein-folding problem in 2020, it showed that artificial intelligence could crack one of biology’s deepest mysteries: how a string of amino acids folds itself into a ...

A massive genomics effort has identified thousands of single nucleotide non-coding variants, which alter gene activity, that link to disease and health.

Long non-coding RNAs (lncRNA) are a type of RNA molecule that do not carry instructions to make proteins. Instead, they influence how other genes are expressed. There are tens of thousands of lncRNAs ...

In a recent study, researchers at the Texas A&M University Health Science Center (Texas A&M Health) identify a novel RNA molecule that plays a crucial role in preserving the integrity of a key ...

A proposed function of TADs is to contribute to gene regulation by promoting chromatin interactions within a TAD and by suppressing interactions between TADs. Here, we directly probe the ...