Researchers have changed the way to look at DNA. They show that DNA is much more than a linear sequence of building blocks; it has a 3D structure that influences the variation of human genome-wide ...

Between any two people, there are likely to be at least 10 million differences in the genetic sequence that makes up their DNA. Most of these differences don't alter the way cells behave or cause ...

This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...

Cancer genomes are the result of diverse mutation processes that have often accumulated over decades. Scientists have analyzed the molecular evolution of tumors after exposure to mutagenic chemicals.

Proteins are like Spider-Man in the multiverse. The underlying story is the same: each building block of a protein is based on a three-letter DNA code. However, change one letter, and the same protein ...

Geneticists looking inside the nuclear genome for mutations that contribute to disease have long relied on a principal known as constraint modeling, which allows researchers to assess the degree of ...

Researchers working on an incurable blood cancer can now use a new lab model that could make testing potential new treatments and diagnostics easier and quicker, new research has found. Working with ...

Treating acute myeloid leukemia (AML) depends on knowing what goes wrong inside cells. A new study suggests that two genetic ...