A basic function of the Mediator complex is to communicate regulatory signals from DNA-binding transcription factors (TFs) directly to RNA polymerase II (Pol II). Different TFs, and the signalling ...

In a major step toward achieving one of the key unsolved problems of structural biochemistry, the crystal structure of a large part of the yeast Mediator protein complex has been determined. Found in ...

Targeted cancer treatments - those that home in on the malignant cells and leave the healthy ones unscathed - have improved outcomes while reducing toxic side effects. But unfortunately, cancer cells ...

Georg Winter's lab at CeMM uses chemical tools to understand the molecular basis of gene control and aberrations thereof in cancer. To do so, the team combines particularly fast-acting protein ...