Mast cell activation syndrome (MCAS) is a condition that occurs when the mast cells in your body release too much of a substance that causes allergy-like symptoms. Mast cells are part of your immune ...

Mast cell leukemia (MCL) is a quick-progressing condition that leads to the buildup of mast cells in your bone marrow and other tissues. It falls into a group of diseases collectively known as ...

Immune cell trapping during allergic responses Mast cells, residing in tissues and critical for initiating inflammation, are filled with granules containing pro-inflammatory substances. These granules ...

Mast cells are a crucial part of our immune defenses against bacteria, some parasites and venoms, but they are also key players in allergic reactions, in which inflammatory mediators, such as ...

Mast cells develop from hematopoietic progenitors in response to stem-cell factor (KIT ligand), which is the ligand of the CD117 transmembrane tyrosine kinase receptor, encoded by KIT. CD117 regulates ...

Mast cells are a type of innate immune cell. They contain large granules that are packed with immunomodulatory and vasoactive molecules, which are released following mast cell degranulation. Mast ...

Q: My doctor thinks my mast cells are activating inappropriately and may be causing many of the symptoms I periodically have. Please tell me more about this condition. A: Mast cells are an important ...

Mast cell precursor cells do not just cause an increase in mature mast cells during inflammation, they also play an active role in diseases like asthma, according to a new study. Mast cell precursor ...

Mast cell activation syndrome, or disease (MCAS), is a condition that causes mast cells to release these substances too frequently, resulting in severe allergic reactions. After detecting an allergen, ...