Researchers have developed a new enzyme engineering platform to improve plastic degrading enzymes through directed evolution. Researchers from the Manchester Institute of Biotechnology (MIB) have ...

Using computational design and directed evolution, scientists have successfully created a metalloprotein that can catalyze a commonly used organic reaction more efficiently than any known enzyme (Nat.

During the last 50 years, an abundance of data has been gathered on the function of lipids as a source of energy, as building blocks, and as signaling molecules in living systems. Lipid-signaling ...

Directed evolution—a process in which a protein library is subjected to repeated rounds of mutation and selection to achieve desired properties—can improve the catalytic performance of computationally ...

Chemists created an enzyme with boronic acid at its reactive center. This approach can produce more selective reactions with boron, and allows the use of directed evolution to improve its catalytic ...

Enzymes catalyze chemical reactions in organisms—without which life would not be possible. Leveraging AlphaFold2 artificial intelligence, researchers at Charité—Universitätsmedizin Berlin have now ...

For the first time, scientists have engineered an enzyme that can break stubborn man-made bonds between silicon and carbon that exist in widely used chemicals known as siloxanes, or silicones. The ...

The rational design of enzymes is an important goal for both fundamental and practical reasons. Here, we describe a process to learn the constraints for specifying proteins purely from evolutionary ...

Researchers at MIT have made a major breakthrough in optimizing rubisco, a key enzyme in photosynthesis. By modifying a bacterial version of this molecule, they achieved a 25% higher catalytic ...