Clathrin is known for its role in coating various transport vesicles inside the cell. Mammalian clathrin is composed of heavy and light chains that form a three-legged protein complex called a ...

In clathrin-mediated endocytosis, the cell membrane invaginates to take up metabolites, hormones, and proteins from the cell surface into intracellular vesicles. Cells employ several pathways for ...

Clathrin-mediated endocytosis (CME) is vital for the internalization of most cell-surface proteins. In CME, plasma membrane–binding clathrin adaptors recruit and polymerize clathrin to form ...

After it fills with cargo, the pit pinches off to form a clathrin-coated, membrane-bound vesicle inside the cell, which then proceeds to its proper destination. In cultured cells, hundreds of these ...

Chao Wang, Tianwei Hu, Xu Yan, Tingting Meng, Yutong Wang, Qingmei Wang, Xiaoyue Zhang, Ying Gu, Clara Sánchez-Rodríguez, Astrid Gadeyne, Jinxing Lin, Staffan Persson, Daniël Van Damme, Chuanyou Li, ...

This study is reported by Hualan Chen’s group from the State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences.

Clathrin coated pits (CCPs) are spherical, cage-like structures located on the plasma membrane that are responsible for receptor-mediated endocytosis. CCPs bud off the cell membrane with their ...

The paper S. Kaur et al., “An unmet actin requirement explains the mitotic inhibition of clathrin-mediated endocytosis,” eLife, 3:e00829, 2014. For decades, scientists observed clathrin-mediated ...

Endocytosis is a cellular process whereby molecules that cannot pass through a cell membrane passively are actively transported from the extracellular environment into the intracellular environment.

Cells have a clever way called clathrin-mediated endocytosis to transport cargos like growth factors across the cell membrane and into the cell. Researchers used a sophisticated fluorescence ...