Complete disruption of the CXCR4 chemokine receptor gene is embryologically lethal in mice, 11, 12 impeding direct study of CXCR4-mediated tumor progression and metastasis. Current approaches to study ...

Multiple myeloma (MM) is a deadly hematopoietic malignancy characterized by proliferation of malignant plasma cells in the bone marrow (BM) and bone disease. Interactions between myeloma and BM cells ...

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

BERLIN, DE / ACCESS Newswire / October 6, 2025 / Pentixapharm Holding AG (Frankfurt Prime Standard:PTP), an advanced clinical-stage biotech developing novel radiopharmaceuticals, today announced the ...

An evaluation of the role of Src in renal cancer. Background: CXCR4, a chemokine receptor, is implicated in the metastastic process. Higher expression of CXCR4 in renal cell carcinoma predicts shorter ...

Aberrant CXCR4/CXCL12 signaling is involved in many pathophysiological processes such as cancer and inflammatory diseases. A natural fragment of serum albumin, named EPI-X4, has previously been ...

Effect of adjuvant treatment on the circulating CK-19 mRNA-positive tumor cells in patients with early stage breast cancer This is an ASCO Meeting Abstract from the 2006 ASCO Annual Meeting. This ...

Immune cells play a key role during pregnancy, adjusting immune system response in a way that enables the fetus to develop while also protecting the parent and fetus from outside assaults like viruses ...

CAMBRIDGE, Mass.--(BUSINESS WIRE)--X4 Pharmaceuticals today announced the launch of the company’s development strategy for its pipeline of C-X-C receptor type 4 (CXCR4 inhibitors), including two ...

Dr. Susan Schwab and her lab at the NYU Langone Medical Center have associated CXCR4 signaling as a positive regulator of T-cell acute lymphoblastic leukemia (T-ALL) growth and disease progression.

ALX40-4C NPS Allelix Terminated (Phase I/II) HIV No apparent effect was observed on viral load AMD3100 AnorMED Terminated (Phase I/II) HIV Little effect was observed on viral load AMD3100 (plerixafor) ...