Researchers show that loss of the SPRTN enzyme lets DNA–protein crosslinks accumulate, leak DNA into the cytoplasm, activate ...

DNA's iconic double helix does more than "just" store genetic information. Under certain conditions it can temporarily fold into unusual shapes. Researchers at Umeå University, Sweden, have now shown ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal ...

DNA’s iconic double helix does more than “just” store genetic information. Under certain conditions it can temporarily fold into unusual shapes. Researchers at Umeå University, Sweden, have now shown ...

DNA, though tightly packed in the nucleus, is constantly threatened by damage from metabolism and external stressors. One particularly severe form of DNA damage is the so-called DNA–protein crosslinks ...

For almost 60 years, scientists have tried to understand why DNA doesn't replicate wildly and uncontrollably every time a ...

Scientists have discovered that a protein once thought to simply help load a factor necessary for the copying of DNA, plays a ...

Although DNA is tightly packed and safeguarded within the cell nucleus, it remains continually at risk of damage from normal ...

BUFFALO, N.Y. – New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no ...

DNA repair is essential for the maintenance of genomic stability and its failure can lead to human disease. Various DNA repair systems exist, such as base excision repair, nucleotide excision repair, ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by researchers at Goethe ...