Over the past decade, small molecule kinase inhibitors have emerged as promising therapeutics, particularly in oncology. Through data that has emerged during this period, it has become increasingly ...

Establishing that a molecule engages with its intended target protein in cells is an essential step in drug discovery and chemical probe development. The term “target engagement” refers to a chemical ...

Kinases constitute a family of more than 500 enzymes and play critical roles in cellular signaling, both in normal and diseased cells. As a result, kinases continue to be key drug targets, especially ...

Developing new pharmaceuticals is a complex and costly process that requires innovation and efficiency. High-throughput immunoassays (HTIs) are an emerging technology poised to accelerate the drug ...

Martin Clasby receives funding from the National Institutes of Health and Michigan Drug Discovery. Modern drug discovery is an expensive and complicated process. Hundreds of scientists and at least a ...

A novel high-throughput screening assay is designed to identify inhibitors of the androgen receptor, which plays a critical role in the progression of prostate cancer. The assay could be used to ...