A microglia replacement approach demonstrates that brain macrophages with patient mutations from Aicardi–Goutières syndrome, a genetic, brain predominant interferonopathy, are sufficient to drive ...
Neurodegenerative diseases affect about 15 % of the global population and are on the rise due to aging demographics. Neuroinflammation, driven by the brain’s immune cells known as microglia, is a key ...
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a progressive neurological disease with an average age of onset at 43 years and an average life expectancy of only ...
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